Try moving the physical USB key to a different port (avoid USB 3.0 ports for older X7 keys). Mastercam X7-2022 Virtual Usb Bus Error 39 - Google Groups

Here is the story behind that error message.

Until then, keep your feeds high, your speeds low, and your virtual USB bus error-free.

Windows Defender or third-party AV tools often flag virtual USB drivers as "Trojan" or "Riskware," sequestering the necessary DLL files.